Ontology highlight
ABSTRACT:
SUBMITTER: Hammami A
PROVIDER: S-EPMC4457842 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Hammami Akil A Charpentier Tania T Smans Mélina M Stäger Simona S
PLoS pathogens 20150605 6
Inflammation is known to be necessary for promoting, sustaining, and tuning CD8+ T cell responses. Following experimental Leishmania donovani infection, the inflammatory response is mainly induced by the transcription factor IRF-5. IRF-5 is responsible for the activation of several genes encoding key pro-inflammatory cytokines, such as IL-6 and TNF. Here, we investigate the role of IRF-5-mediated inflammation in regulating antigen-specific CD8+ T cell responses during L. donovani infection. Our ...[more]