Ontology highlight
ABSTRACT:
SUBMITTER: Lu M
PROVIDER: S-EPMC6185914 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Lu Mengxin M Ge Qiangqiang Q Wang Gang G Luo Yongwen Y Wang Xiaolong X Jiang Wei W Liu Xuefeng X Wu Chin-Lee CL Xiao Yu Y Wang Xinghuan X
Cell death & disease 20181012 10
Cold-inducible RNA binding protein (CIRBP) has been reported to be associated with distinct tumorigenesis. In this study, we investigated the role of CIRBP in human bladder cancer (BCa), indicating that CIRBP is overexpressed in BCa tissues and cell lines to promote proliferation and migration. Moreover, CIRBP could induce expression of HIF-1α via binding to the 3'-UTR of its mRNA to increase the mRNA stability in BCa cells. Furthermore, we demonstrated that PTGIS is a HIF-1α targeted gene, a ma ...[more]