Ontology highlight
ABSTRACT:
SUBMITTER: Thompson R
PROVIDER: S-EPMC4458193 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Thompson Ruth R Shah Richa B RB Liu Peter H PH Gupta Yogesh K YK Ando Kiyohiro K Aggarwal Aneel K AK Sidi Samuel S
Molecular cell 20150430 5
The PIDDosome-PIDD-RAIDD-caspase-2 complex-is a proapoptotic caspase-activation platform of elusive significance. DNA damage can initiate complex assembly via ATM phosphorylation of the PIDD death domain (DD), which enables RAIDD recruitment to PIDD. In contrast, the mechanisms limiting PIDDosome formation have remained unclear. We identify the mitotic checkpoint factor BubR1 as a direct PIDDosome inhibitor, acting in a noncanonical role independent of Mad2. Following its phosphorylation by ATM ...[more]