Ontology highlight
ABSTRACT:
SUBMITTER: Ando K
PROVIDER: S-EPMC3444620 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Ando Kiyohiro K Kernan Jennifer L JL Liu Peter H PH Sanda Takaomi T Logette Emmanuelle E Tschopp Jurg J Look A Thomas AT Wang Jianlong J Bouchier-Hayes Lisa L Sidi Samuel S
Molecular cell 20120730 5
Biochemical evidence implicates the death-domain (DD) protein PIDD as a molecular switch capable of signaling cell survival or death in response to genotoxic stress. PIDD activity is determined by binding-partner selection at its DD: whereas recruitment of RIP1 triggers prosurvival NF-κB signaling, recruitment of RAIDD activates proapoptotic caspase-2 via PIDDosome formation. However, it remains unclear how interactor selection, and thus fate decision, is regulated at the PIDD platform. We show ...[more]