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Dengue in adults admitted to a referral hospital in Hanoi, Vietnam.

ABSTRACT: Knowledge of adult dengue virus (DENV) infection from Hanoi, Vietnam, is limited. In 2008, we prospectively studied 143 (77 male) confirmed (nonstructural 1 antigen enzyme-linked immunosorbent assay [ELISA], DENV polymerase chain reaction, paired serology) adult dengue patients of median age 23.5 (range 16-72) years. They were admitted to the National Hospital for Tropical Diseases, Hanoi, on median illness day (D) 5 (range 1-8). By D8, 141 (98.6%) were afebrile. Platelet counts and hematocrit (median, interquartile range [IQR]) nadired and peaked on D5 and D4, respectively: 40,000/μL (10,000-109,000/μL), 43.4% (34.9-49.7%). Four (2.8%) patients had severe dengue: 1) D10 shock (N = 1) and 2) aspartate aminotransferase (AST) ≥ 1,000 IU/L (N = 3, D5 and D7). Of 143 patients, 118 (82.5%) had ≥ 1 warning sign (World Health Organization [WHO] 2009 criteria): mucosal bleeding 66/143 (46.1%), soft tissue edema 54/143 (37.7%), and ultrasound detected plasma leakage (pleural effusions/ascites) 30/129 (23.25%). 138 (96.5%) patients received intravenous (IV) fluids: 3 L (IQR: 0.5-8.5 L). Most patients had non-severe dengue with warning signs. High rates of edema and plasma leakage may be explained partly by liberal use of IV fluids. Studies are needed on optimizing fluid management in non-severe adult dengue.

SUBMITTER: Taylor WR

PROVIDER: S-EPMC4458817 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Dengue in adults admitted to a referral hospital in Hanoi, Vietnam.

Taylor Walter R WR Fox Annette A Pham Khuong Thi KT Le Hoa Nguyen Minh HNM Tran Ninh Thi Hai NTH Tran Giang Van GV Nguyen Binh Thanh BT Nguyen My Van MV Nguyen Lien Thi LT Yacoub Sophie S Nguyen Hoai Thi Thu HTT Nguyen Ha Hong HH Nguyen Hien Duc HD Wertheim Heiman H Horby Peter P Farrar Jeremy J Trinh Lien Thi Minh LTM Nguyen Kinh Van KV

The American journal of tropical medicine and hygiene 20150427 6

Knowledge of adult dengue virus (DENV) infection from Hanoi, Vietnam, is limited. In 2008, we prospectively studied 143 (77 male) confirmed (nonstructural 1 antigen enzyme-linked immunosorbent assay [ELISA], DENV polymerase chain reaction, paired serology) adult dengue patients of median age 23.5 (range 16-72) years. They were admitted to the National Hospital for Tropical Diseases, Hanoi, on median illness day (D) 5 (range 1-8). By D8, 141 (98.6%) were afebrile. Platelet counts and hematocrit ( ...[more]

PMID: 25918201

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Dengue in adults admitted to a referral hospital in Hanoi, Vietnam.

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Dengue in adults admitted to a referral hospital in Hanoi, Vietnam.

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