Ontology highlight
ABSTRACT:
SUBMITTER: Perez-Sala D
PROVIDER: S-EPMC4458873 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Pérez-Sala Dolores D Oeste Clara L CL Martínez Alma E AE Carrasco M Jesús MJ Garzón Beatriz B Cañada F Javier FJ
Nature communications 20150602
The vimentin filament network plays a key role in cell architecture and signalling, as well as in epithelial-mesenchymal transition. Vimentin C328 is targeted by various oxidative modifications, but its role in vimentin organization is not known. Here we show that C328 is essential for vimentin network reorganization in response to oxidants and electrophiles, and is required for optimal vimentin performance in network expansion, lysosomal distribution and aggresome formation. C328 may fulfil the ...[more]