Ontology highlight
ABSTRACT:
SUBMITTER: Gruszka DT
PROVIDER: S-EPMC4458895 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Gruszka Dominika T DT Whelan Fiona F Farrance Oliver E OE Fung Herman K H HK Paci Emanuele E Jeffries Cy M CM Svergun Dmitri I DI Baldock Clair C Baumann Christoph G CG Brockwell David J DJ Potts Jennifer R JR Clarke Jane J
Nature communications 20150601
Bacteria exploit surface proteins to adhere to other bacteria, surfaces and host cells. Such proteins need to project away from the bacterial surface and resist significant mechanical forces. SasG is a protein that forms extended fibrils on the surface of Staphylococcus aureus and promotes host adherence and biofilm formation. Here we show that although monomeric and lacking covalent cross-links, SasG maintains a highly extended conformation in solution. This extension is mediated through obliga ...[more]