A common variant near TGFBR3 is associated with primary open angle glaucoma.
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ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC4459396 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
A common variant near TGFBR3 is associated with primary open angle glaucoma.
Li Zheng Z Allingham R Rand RR Nakano Masakazu M Jia Liyun L Chen Yuhong Y Ikeda Yoko Y Mani Baskaran B Chen Li-Jia LJ Kee Changwon C Garway-Heath David F DF Sripriya Sarangapani S Fuse Nobuo N Abu-Amero Khaled K KK Huang Chukai C Namburi Prasanthi P Burdon Kathryn K Perera Shamira A SA Gharahkhani Puya P Lin Ying Y Ueno Morio M Ozaki Mineo M Mizoguchi Takanori T Krishnadas Subbiah Ramasamy SR Osman Essam A EA Lee Mei Chin MC Chan Anita S Y AS Tajudin Liza-Sharmini A LS Do Tan T Goncalves Aurelien A Reynier Pascal P Zhang Hong H Bourne Rupert R Goh David D Broadway David D Husain Rahat R Negi Anil K AK Su Daniel H DH Ho Ching-Lin CL Blanco Augusto Azuara AA Leung Christopher K S CK Wong Tina T TT Yakub Azhany A Liu Yutao Y Nongpiur Monisha E ME Han Jong Chul JC Hon Do Nhu DN Shantha Balekudaru B Zhao Bowen B Sang Jinghong J Zhang NiHong N Sato Ryuichi R Yoshii Kengo K Panda-Jonas Songhomita S Ashley Koch Allison E AE Herndon Leon W LW Moroi Sayoko E SE Challa Pratap P Foo Jia Nee JN Bei Jin-Xin JX Zeng Yi-Xin YX Simmons Cameron P CP Bich Chau Tran Nguyen TN Sharmila Philomenadin Ferdinamarie PF Chew Merwyn M Lim Blanche B Tam Pansy O S PO Chua Elaine E Ng Xiao Yu XY Yong Victor H K VH Chong Yaan Fun YF Meah Wee Yang WY Vijayan Saravanan S Seongsoo Sohn S Xu Wang W Teo Yik Ying YY Cooke Bailey Jessica N JN Kang Jae H JH Haines Jonathan L JL Cheng Ching Yu CY Saw Seang-Mei SM Tai E-Shyong ES Richards Julia E JE Ritch Robert R Gaasterland Douglas E DE Pasquale Louis R LR Liu Jianjun J Jonas Jost B JB Milea Dan D George Ronnie R Al-Obeidan Saleh A SA Mori Kazuhiko K Macgregor Stuart S Hewitt Alex W AW Girkin Christopher A CA Zhang Mingzhi M Sundaresan Periasamy P Vijaya Lingam L Mackey David A DA Wong Tien Yin TY Craig Jamie E JE Sun Xinghuai X Kinoshita Shigeru S Wiggs Janey L JL Khor Chiea-Chuen CC Yang Zhenglin Z Pang Chi Pui CP Wang Ningli N Hauser Michael A MA Tashiro Kei K Aung Tin T Vithana Eranga N EN
Human molecular genetics 20150410 13
Primary open angle glaucoma (POAG), a major cause of blindness worldwide, is a complex disease with a significant genetic contribution. We performed Exome Array (Illumina) analysis on 3504 POAG cases and 9746 controls with replication of the most significant findings in 9173 POAG cases and 26 780 controls across 18 collections of Asian, African and European descent. Apart from confirming strong evidence of association at CDKN2B-AS1 (rs2157719 [G], odds ratio [OR] = 0.71, P = 2.81 × 10(-33)), we ...[more]
