Ontology highlight
ABSTRACT:
SUBMITTER: Carpinteiro A
PROVIDER: S-EPMC4459814 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Carpinteiro Alexander A Becker Katrin Anne KA Japtok Lukasz L Hessler Gabriele G Keitsch Simone S Požgajovà Miroslava M Schmid Kurt W KW Adams Constantin C Müller Stefan S Kleuser Burkhard B Edwards Michael J MJ Grassmé Heike H Helfrich Iris I Gulbins Erich E
EMBO molecular medicine 20150601 6
Metastatic dissemination of cancer cells is the ultimate hallmark of malignancy and accounts for approximately 90% of human cancer deaths. We investigated the role of acid sphingomyelinase (Asm) in the hematogenous metastasis of melanoma cells. Intravenous injection of B16F10 melanoma cells into wild-type mice resulted in multiple lung metastases, while Asm-deficient mice (Smpd1(-/-) mice) were protected from pulmonary tumor spread. Transplanting wild-type platelets into Asm-deficient mice reins ...[more]