Ontology highlight
ABSTRACT:
SUBMITTER: Alvarez-Zarate J
PROVIDER: S-EPMC4461249 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Alvarez-Zarate Julian J Matlung Hanke L HL Matozaki Takashi T Kuijpers Taco W TW Maridonneau-Parini Isabelle I van den Berg Timo K TK
PloS one 20150609 6
Signaling through the inhibitory receptor signal regulatory protein-alpha (SIRPα) controls effector functions in phagocytes. However, there are also indications that interactions between SIRPα and its ligand CD47 are involved in phagocyte transendothelial migration. We have investigated the involvement of SIRPα signaling in phagocyte migration in vitro and in vivo using mice that lack the SIRPα cytoplasmic tail. During thioglycolate-induced peritonitis in SIRPα mutant mice, both neutrophil and m ...[more]