Regulation of Phagocyte Migration by Signal Regulatory Protein-Alpha Signaling.

ABSTRACT: Signaling through the inhibitory receptor signal regulatory protein-alpha (SIRP?) controls effector functions in phagocytes. However, there are also indications that interactions between SIRP? and its ligand CD47 are involved in phagocyte transendothelial migration. We have investigated the involvement of SIRP? signaling in phagocyte migration in vitro and in vivo using mice that lack the SIRP? cytoplasmic tail. During thioglycolate-induced peritonitis in SIRP? mutant mice, both neutrophil and macrophage influx were found to occur, but to be significantly delayed. SIRP? signaling appeared to be essential for an optimal transendothelial migration and chemotaxis, and for the amoeboid type of phagocyte migration in 3-dimensional environments. These findings demonstrate, for the first time, that SIRP? signaling can directly control phagocyte migration, and this may contribute to the impaired inflammatory phenotype that has been observed in the absence of SIRP? signaling.

SUBMITTER: Alvarez-Zarate J 

PROVIDER: S-EPMC4461249 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature