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Structure of the MarR family protein Rv0880 from Mycobacterium tuberculosis.

ABSTRACT: Rv0880 from the pathogen Mycobacterium tuberculosis is classified as a MarR family protein in the Pfam database. It consists of 143 amino acids and has an isoelectric point of 10.9. Crystals of Rv0880 belonged to space group P1, with unit-cell parameters a = 54.97, b = 69.60, c = 70.32 Å, ? = 103.71, ? = 111.06, ? = 105.83°. The structure of the MarR family transcription regulator Rv0880 was solved at a resolution of 2.0 Å with an R(cryst) and R(free) of 21.2 and 24.9%, respectively. The dimeric structure resembles that of other MarR proteins, with each subunit comprising a winged helix-turn-helix domain connected to an ?-helical dimerization domain.

SUBMITTER: Gao YR

PROVIDER: S-EPMC4461340 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Structure of the MarR family protein Rv0880 from Mycobacterium tuberculosis.

Gao Yun Rong YR Feng Na N Chen Tao T Li De Feng de F Bi Li Jun LJ

Acta crystallographica. Section F, Structural biology communications 20150522 Pt 6

Rv0880 from the pathogen Mycobacterium tuberculosis is classified as a MarR family protein in the Pfam database. It consists of 143 amino acids and has an isoelectric point of 10.9. Crystals of Rv0880 belonged to space group P1, with unit-cell parameters a = 54.97, b = 69.60, c = 70.32 Å, α = 103.71, β = 111.06, γ = 105.83°. The structure of the MarR family transcription regulator Rv0880 was solved at a resolution of 2.0 Å with an R(cryst) and R(free) of 21.2 and 24.9%, respectively. The dimeric ...[more]

PMID: 26057805

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