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Crystal structure of Rv3899c(184-410), a hypothetical protein from Mycobacterium tuberculosis.

ABSTRACT: Rv3899c is a hypothetical protein from Mycobacterium tuberculosis which is conserved across mycobacteria. It is predicted to be secreted and has been found in culture filtrates. It has been proposed as a potential vaccine candidate; however, its biological function is unknown. Here, the global structure of Rv3899c(184-410), a fragment of Rv3899c, is reported. The structure resembles the shell of a sea snail, and its N- and C-termini form two relatively independent compact domains: an ?/?/? sandwich folding domain and an ?-helix bundle domain. There are no reported protein structures for any Rv3899c homologues; this structure provides the first structural glimpse of a new protein family consisting of Rv3899c and its homologues.

SUBMITTER: Liu Y

PROVIDER: S-EPMC4973306 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Crystal structure of Rv3899c(184-410), a hypothetical protein from Mycobacterium tuberculosis.

Liu Yingying Y Gao Yunrong Y Li Defeng D Fleming Joy J Li Honglin H Bi Lijun L

Acta crystallographica. Section F, Structural biology communications 20160727 Pt 8

Rv3899c is a hypothetical protein from Mycobacterium tuberculosis which is conserved across mycobacteria. It is predicted to be secreted and has been found in culture filtrates. It has been proposed as a potential vaccine candidate; however, its biological function is unknown. Here, the global structure of Rv3899c(184-410), a fragment of Rv3899c, is reported. The structure resembles the shell of a sea snail, and its N- and C-termini form two relatively independent compact domains: an α/β/α sandw ...[more]

PMID: 27487929

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