Ontology highlight
ABSTRACT:
SUBMITTER: Madison MN
PROVIDER: S-EPMC4461544 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Madison Marisa N MN Jones Philip H PH Okeoma Chioma M CM
Virology 20150413
Exosomes are membranous extracellular nanovesicles secreted by diverse cell types. Exosomes from healthy human semen have been shown to inhibit HIV-1 replication and to impair progeny virus infectivity. In this study, we examined the ability of healthy human semen exosomes to restrict HIV-1 and LP-BM5 murine AIDS virus transmission in three different model systems. We show that vaginal cells internalize exosomes with concomitant transfer of functional mRNA. Semen exosomes blocked the spread of H ...[more]