Ontology highlight
ABSTRACT:
SUBMITTER: McLellan JS
PROVIDER: S-EPMC4461862 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
McLellan Jason S JS Chen Man M Joyce M Gordon MG Sastry Mallika M Stewart-Jones Guillaume B E GB Yang Yongping Y Zhang Baoshan B Chen Lei L Srivatsan Sanjay S Zheng Anqi A Zhou Tongqing T Graepel Kevin W KW Kumar Azad A Moin Syed S Boyington Jeffrey C JC Chuang Gwo-Yu GY Soto Cinque C Baxa Ulrich U Bakker Arjen Q AQ Spits Hergen H Beaumont Tim T Zheng Zizheng Z Xia Ningshao N Ko Sung-Youl SY Todd John-Paul JP Rao Srinivas S Graham Barney S BS Kwong Peter D PD
Science (New York, N.Y.) 20131101 6158
Respiratory syncytial virus (RSV) is the leading cause of hospitalization for children under 5 years of age. We sought to engineer a viral antigen that provides greater protection than currently available vaccines and focused on antigenic site Ø, a metastable site specific to the prefusion state of the RSV fusion (F) glycoprotein, as this site is targeted by extremely potent RSV-neutralizing antibodies. Structure-based design yielded stabilized versions of RSV F that maintained antigenic site Ø ...[more]