Ontology highlight
ABSTRACT:
SUBMITTER: Flynn JA
PROVIDER: S-EPMC5072732 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Flynn Jessica A JA Durr Eberhard E Swoyer Ryan R Cejas Pedro J PJ Horton Melanie S MS Galli Jennifer D JD Cosmi Scott A SA Espeseth Amy S AS Bett Andrew J AJ Zhang Lan L
PloS one 20161020 10
Infection with Respiratory Syncytial Virus (RSV) causes both upper and lower respiratory tract disease in humans, leading to significant morbidity and mortality in both young children and older adults. Currently, there is no licensed vaccine available, and therapeutic options are limited. During the infection process, the type I viral fusion (F) glycoprotein on the surface of the RSV particle rearranges from a metastable prefusion conformation to a highly stable postfusion form. In people natura ...[more]