MicroRNA regulation of the embryonic hypoxic response in Caenorhabditis elegans.
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ABSTRACT:
SUBMITTER: Kagias K
PROVIDER: S-EPMC4462753 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
microRNA regulation of the embryonic hypoxic response in Caenorhabditis elegans.
Kagias Konstantinos K Pocock Roger R
Scientific reports 20150611
Layered strategies to combat hypoxia provide flexibility in dynamic oxygen environments. Here we show that multiple miRNAs are required for hypoxic survival responses during C. elegans embryogenesis. Certain miRNAs promote while others antagonize the hypoxic survival response. We found that expression of the mir-35 family is regulated by hypoxia in a HIF-1-independent manner and loss of mir-35-41 weakens hypoxic survival mechanisms in embryos. In addition, correct regulation of the RNA binding p ...[more]
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