Ontology highlight
ABSTRACT:
SUBMITTER: Mehta R
PROVIDER: S-EPMC2737476 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20090416 5931
The Caenorhabditis elegans von Hippel-Lindau tumor suppressor homolog VHL-1 is a cullin E3 ubiquitin ligase that negatively regulates the hypoxic response by promoting ubiquitination and degradation of the hypoxic response transcription factor HIF-1. Here, we report that loss of VHL-1 significantly increased life span and enhanced resistance to polyglutamine and beta-amyloid toxicity. Deletion of HIF-1 was epistatic to VHL-1, indicating that HIF-1 acts downstream of VHL-1 to modulate aging and p ...[more]