Ontology highlight
ABSTRACT:
SUBMITTER: Pecchioli T
PROVIDER: S-EPMC4463494 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20150512
The first immobilization of a MacMillan's first generation organocatalyst onto dendritic support is described. A modified tyrosine-based imidazolidin-4-one was grafted to a soluble high-loading hyperbranched polyglycerol via a copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction and readily purified by dialysis. The efficiency of differently functionalized multivalent organocatalysts 4a-c was tested in the asymmetric Friedel-Crafts alkylation of N-methylpyrrole with α,β-unsaturated aldeh ...[more]