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Structural Insights into tRNA Dynamics on the Ribosome.

ABSTRACT: High-resolution structures at different stages, as well as biochemical, single molecule and computational approaches have highlighted the elasticity of tRNA molecules when bound to the ribosome. It is well acknowledged that the inherent structural flexibility of the tRNA lies at the heart of the protein synthesis process. Here, we review the recent advances and describe considerations that the conformational changes of the tRNA molecules offer about the mechanisms grounded in translation.

SUBMITTER: Agirrezabala X

PROVIDER: S-EPMC4463622 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Structural Insights into tRNA Dynamics on the Ribosome.

Agirrezabala Xabier X Valle Mikel M

International journal of molecular sciences 20150430 5

High-resolution structures at different stages, as well as biochemical, single molecule and computational approaches have highlighted the elasticity of tRNA molecules when bound to the ribosome. It is well acknowledged that the inherent structural flexibility of the tRNA lies at the heart of the protein synthesis process. Here, we review the recent advances and describe considerations that the conformational changes of the tRNA molecules offer about the mechanisms grounded in translation. ...[more]

PMID: 25941930

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