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Design, synthesis and photochemical properties of the first examples of iminosugar clusters based on fluorescent cores.

ABSTRACT: The synthesis and photophysical properties of the first examples of iminosugar clusters based on a BODIPY or a pyrene core are reported. The tri- and tetravalent systems designed as molecular probes and synthesized by way of Cu(I)-catalysed azide-alkyne cycloadditions are fluorescent analogues of potent pharmacological chaperones/correctors recently reported in the field of Gaucher disease and cystic fibrosis, two rare genetic diseases caused by protein misfolding.

SUBMITTER: Lepage ML 

PROVIDER: S-EPMC4464267 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Design, synthesis and photochemical properties of the first examples of iminosugar clusters based on fluorescent cores.

Lepage Mathieu L ML   Mirloup Antoine A   Ripoll Manon M   Stauffert Fabien F   Bodlenner Anne A   Ziessel Raymond R   Compain Philippe P  

Beilstein journal of organic chemistry 20150506

The synthesis and photophysical properties of the first examples of iminosugar clusters based on a BODIPY or a pyrene core are reported. The tri- and tetravalent systems designed as molecular probes and synthesized by way of Cu(I)-catalysed azide-alkyne cycloadditions are fluorescent analogues of potent pharmacological chaperones/correctors recently reported in the field of Gaucher disease and cystic fibrosis, two rare genetic diseases caused by protein misfolding. ...[more]

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