Ontology highlight
ABSTRACT:
SUBMITTER: Henry C
PROVIDER: S-EPMC4464552 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Henry Cyril C Bolien David D Ibanescu Bogdan B Bloodworth Sally S Harrowven David C DC Zhang Xunli X Craven Andy A Sneddon Helen F HF Whitby Richard J RJ
European journal of organic chemistry 20150120 7
Ketenes were generated by the thermolysis of alkoxyalkynes under flow conditions, and then trapped with amines and alcohols to cleanly give amides and esters. For a 10 min reaction time, temperatures of 180, 160, and 140 °C were required for >95 % conversion of EtO, <i>i</i>PrO, and <i>t</i>BuO alkoxyalkynes, respectively. Variation of the temperature and flow rate with inline monitoring of the output by IR spectroscopy allowed the kinetic parameters for the conversion of 1-ethoxy-1-octyne to be ...[more]