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Synthesis of pyrimido[1,6-a]quinoxalines via intermolecular trapping of thermally generated acyl(quinoxalin-2-yl)ketenes by Schiff bases.

ABSTRACT: Acyl(quinoxalin-2-yl)ketenes generated by thermal decarbonylation of 3-acylpyrrolo[1,2-a]quinoxaline-1,2,4(5H)-triones react regioselectively with Schiff bases under solvent-free conditions to form pyrimido[1,6-a]quinoxaline derivatives in good yields.

SUBMITTER: Kasatkina SO

PROVIDER: S-EPMC6071730 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Synthesis of pyrimido[1,6-a]quinoxalines via intermolecular trapping of thermally generated acyl(quinoxalin-2-yl)ketenes by Schiff bases.

Kasatkina Svetlana O SO Stepanova Ekaterina E EE Dmitriev Maksim V MV Mokrushin Ivan G IG Maslivets Andrey N AN

Beilstein journal of organic chemistry 20180711

Acyl(quinoxalin-2-yl)ketenes generated by thermal decarbonylation of 3-acylpyrrolo[1,2-a]quinoxaline-1,2,4(5H)-triones react regioselectively with Schiff bases under solvent-free conditions to form pyrimido[1,6-a]quinoxaline derivatives in good yields. ...[more]

PMID: 30112078

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