Ontology highlight
ABSTRACT:
SUBMITTER: Peters HL
PROVIDER: S-EPMC4466200 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20150523 15
A series of doubly flexible nucleoside analogues were designed based on the acyclic sugar scaffold of acyclovir and the flex-base moiety found in the fleximers. The target compounds were evaluated for their antiviral potential and found to inhibit several coronaviruses. Significantly, compound 2 displayed selective antiviral activity (CC50 >3× EC50) towards human coronavirus (HCoV)-NL63 and Middle East respiratory syndrome-coronavirus, but not severe acute respiratory syndrome-coronavirus. In th ...[more]