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ABSTRACT:
SUBMITTER: Gazivoda T
PROVIDER: S-EPMC7127491 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry 20080401 10
A series of the novel C-5 alkynyl pyrimidine nucleoside analogues (1-14) in which the sugar moiety was replaced by the conformationally restricted Z- and E-2-butenyl spacer between the phthalimido and pyrimidine ring were synthesized by using Sonogashira cross-coupling reaction. Cytostatic activity evaluation of the novel compounds showed that E-isomers exhibited, in general, better cytostatic activities than the corresponding Z-isomers. E-isomer 14 exhibited the best cytostatic effect against a ...[more]