Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1.
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ABSTRACT:
SUBMITTER: Curtis AM
PROVIDER: S-EPMC4466714 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1.
Curtis Anne M AM Fagundes Caio T CT Yang Guangrui G Palsson-McDermott Eva M EM Wochal Paulina P McGettrick Anne F AF Foley Niamh H NH Early James O JO Chen Lihong L Zhang Hanrui H Xue Chenyi C Geiger Sarah S SS Hokamp Karsten K Reilly Muredach P MP Coogan Andrew N AN Vigorito Elena E FitzGerald Garret A GA O'Neill Luke A J LA
Proceedings of the National Academy of Sciences of the United States of America 20150520 23
The response to an innate immune challenge is conditioned by the time of day, but the molecular basis for this remains unclear. In myeloid cells, there is a temporal regulation to induction by lipopolysaccharide (LPS) of the proinflammatory microRNA miR-155 that correlates inversely with levels of BMAL1. BMAL1 in the myeloid lineage inhibits activation of NF-κB and miR-155 induction and protects mice from LPS-induced sepsis. Bmal1 has two miR-155-binding sites in its 3'-UTR, and, in response to ...[more]
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