Phospho-TCTP as a therapeutic target of Dihydroartemisinin for aggressive breast cancer cells.
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ABSTRACT:
SUBMITTER: Lucibello M
PROVIDER: S-EPMC4467148 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Publications
Phospho-TCTP as a therapeutic target of Dihydroartemisinin for aggressive breast cancer cells.
Lucibello Maria M Adanti Sara S Antelmi Ester E Dezi Dario D Ciafrè Stefania S Carcangiu Maria Luisa ML Zonfrillo Manuela M Nicotera Giuseppe G Sica Lorenzo L De Braud Filippo F Pierimarchi Pasquale P
Oncotarget 20150301 7
Upregulation of Translationally Controlled Tumor Protein (TCTP) is associated with poorly differentiated aggressive tumors, including breast cancer, but the underlying mechanism(s) are still debated. Here, we show that in breast cancer cell lines TCTP is primarily localized in the nucleus, mostly in the phosphorylated form.The effects of Dihydroartemisinin (DHA), an anti-malaria agent that binds TCTP, were tested on breast cancer cells. DHA decreases cell proliferation and induces apoptotic cell ...[more]
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