Ontology highlight
ABSTRACT:
SUBMITTER: Connolly R
PROVIDER: S-EPMC3515719 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Connolly Roisin R Stearns Vered V
Journal of mammary gland biology and neoplasia 20120727 3-4
Epigenetics refers to alterations in gene expression due to modifications in histone acetylation and DNA methylation at the promoter regions of genes. Unlike genetic mutations, epigenetic alterations are not due to modifications in the gene primary nucleotide sequence. The importance of epigenetics in the initiation and progression of breast cancer has led many investigators to incorporate this novel and exciting field in breast cancer drug development. Several drugs that target epigenetic alter ...[more]