Ontology highlight
ABSTRACT:
SUBMITTER: Mootz JM
PROVIDER: S-EPMC4467170 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Mootz Joe M JM Benson Meredith A MA Heim Cortney E CE Crosby Heidi A HA Kavanaugh Jeffrey S JS Dunman Paul M PM Kielian Tammy T Torres Victor J VJ Horswill Alexander R AR
Molecular microbiology 20150226 2
Staphylococcus aureus is a significant cause of chronic biofilm infections on medical implants. We investigated the biofilm regulatory cascade and discovered that the repressor of toxins (Rot) is part of this pathway. A USA300 community-associated methicillin-resistant S. aureus strain deficient in Rot was unable to form a biofilm using multiple different assays, and we found rot mutants in other strain lineages were also biofilm deficient. By performing a global analysis of transcripts and prot ...[more]