Ontology highlight
ABSTRACT:
SUBMITTER: Leung WY
PROVIDER: S-EPMC4467394 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Leung Wing-yin WY Roxanis Ioannis I Sheldon Helen H Buffa Francesca M FM Li Ji-liang JL Harris Adrian L AL Kong Anthony A
Oncotarget 20150301 8
Acquired resistance to lapatinib, an inhibitor of EGFR and HER2 kinases, is common. We found that reactivation of EGFR, HER2 and HER3 occurred within 24 hours of lapatinib treatment after their initial dephosphorylation. This was associated with increased expression of NRG1 in cells treated with lapatinib. Exogenous NRG1 partially rescued breast cancer cells from growth inhibition by lapatinib. In addition, both parental and lapatinib-resistant breast cancer cells were sensitive to SGP1, which i ...[more]