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Abnormal Olfaction in Parkinson's Disease Is Related to Faster Disease Progression.


ABSTRACT:

Introduction

A possible association between olfactory dysfunction and Parkinson's disease (PD) severity has been a topic of contention for the past 40 years. Conflicting reports may be partially explained by procedural differences in olfactory assessment and motor symptom evaluation.

Methods

One hundred and sixty-six nondemented PD patients performed the Brief-Smell Identification Test and test scores below the estimated 20th percentile as a function of sex, age, and education (i.e., 80% specificity) were considered demographically abnormal. Patients underwent motor examination after 12?h without antiparkinsonian medication.

Results

Eighty-two percent of PD patients had abnormal olfaction. Abnormal performance on the Brief-Smell Identification Test was associated with higher disease severity (i.e., Hoehn and Yahr, Unified Parkinson's Disease Rating Scale-III, Freezing of Gait questionnaire, and levodopa equivalent dose), even when disease duration was taken into account.

Conclusions

Abnormal olfaction in PD is associated with increased severity and faster disease progression.

SUBMITTER: Cavaco S 

PROVIDER: S-EPMC4468273 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Abnormal Olfaction in Parkinson's Disease Is Related to Faster Disease Progression.

Cavaco Sara S   Gonçalves Alexandra A   Mendes Alexandre A   Vila-Chã Nuno N   Moreira Inês I   Fernandes Joana J   Damásio Joana J   Teixeira-Pinto Armando A   Bastos Lima António A  

Behavioural neurology 20150602


<h4>Introduction</h4>A possible association between olfactory dysfunction and Parkinson's disease (PD) severity has been a topic of contention for the past 40 years. Conflicting reports may be partially explained by procedural differences in olfactory assessment and motor symptom evaluation.<h4>Methods</h4>One hundred and sixty-six nondemented PD patients performed the Brief-Smell Identification Test and test scores below the estimated 20th percentile as a function of sex, age, and education (i.  ...[more]

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