Abnormal Olfaction in Parkinson's Disease Is Related to Faster Disease Progression.
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ABSTRACT: Introduction
A possible association between olfactory dysfunction and Parkinson's disease (PD) severity has been a topic of contention for the past 40 years. Conflicting reports may be partially explained by procedural differences in olfactory assessment and motor symptom evaluation.Methods
One hundred and sixty-six nondemented PD patients performed the Brief-Smell Identification Test and test scores below the estimated 20th percentile as a function of sex, age, and education (i.e., 80% specificity) were considered demographically abnormal. Patients underwent motor examination after 12?h without antiparkinsonian medication.Results
Eighty-two percent of PD patients had abnormal olfaction. Abnormal performance on the Brief-Smell Identification Test was associated with higher disease severity (i.e., Hoehn and Yahr, Unified Parkinson's Disease Rating Scale-III, Freezing of Gait questionnaire, and levodopa equivalent dose), even when disease duration was taken into account.Conclusions
Abnormal olfaction in PD is associated with increased severity and faster disease progression.
SUBMITTER: Cavaco S
PROVIDER: S-EPMC4468273 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Abnormal Olfaction in Parkinson's Disease Is Related to Faster Disease Progression.
Cavaco Sara S Gonçalves Alexandra A Mendes Alexandre A Vila-Chã Nuno N Moreira Inês I Fernandes Joana J Damásio Joana J Teixeira-Pinto Armando A Bastos Lima António A
Behavioural neurology 20150602
<h4>Introduction</h4>A possible association between olfactory dysfunction and Parkinson's disease (PD) severity has been a topic of contention for the past 40 years. Conflicting reports may be partially explained by procedural differences in olfactory assessment and motor symptom evaluation.<h4>Methods</h4>One hundred and sixty-six nondemented PD patients performed the Brief-Smell Identification Test and test scores below the estimated 20th percentile as a function of sex, age, and education (i. ...[more]
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