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Multiple cyp51A-based mechanisms identified in azole-resistant isolates of Aspergillus fumigatus from China.

ABSTRACT: Seventy-two A. fumigatus clinical isolates from China were investigated for azole resistance based on mutations of cyp51A. We identified four azole-resistant strains, among which we found three strains highly resistant to itraconazole, two of which exhibit the TR34/L98H/S297T/F495I mutation, while one carries only the TR34/L98H mutation. To our knowledge, the latter has not been found previously in China. The fourth multiazole-resistant isolate (with only moderate itraconazole resistance) carries a new G432A mutation.

SUBMITTER: Liu M

PROVIDER: S-EPMC4468671 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Multiple cyp51A-based mechanisms identified in azole-resistant isolates of Aspergillus fumigatus from China.

Liu Musang M Zeng Rong R Zhang Lili L Li Dongmei D Lv Guixia G Shen Yongnian Y Zheng Hailin H Zhang Qiangqiang Q Zhao Jingjun J Zheng Nan N Liu Weida W

Antimicrobial agents and chemotherapy 20150420 7

Seventy-two A. fumigatus clinical isolates from China were investigated for azole resistance based on mutations of cyp51A. We identified four azole-resistant strains, among which we found three strains highly resistant to itraconazole, two of which exhibit the TR34/L98H/S297T/F495I mutation, while one carries only the TR34/L98H mutation. To our knowledge, the latter has not been found previously in China. The fourth multiazole-resistant isolate (with only moderate itraconazole resistance) carrie ...[more]

PMID: 25896700

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