Ontology highlight
ABSTRACT:
SUBMITTER: Chen P
PROVIDER: S-EPMC6986205 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Chen Peiying P Liu Musang M Zeng Qiuqiong Q Zhang Zheng Z Liu Weida W Sang Hong H Lu Ling L
Frontiers in microbiology 20200121
The opportunistic pathogen <i>Aspergillus fumigatus</i> has developed worldwide resistance to azoles largely through mutations in cytochromeP450 enzyme Cyp51. In this study, we indicated that <i>in vitro</i> azole situation results in emergence of azole-resistant mutations. There are previously identified azole-resistant <i>cyp51A</i> mutations (M220K, M220I, M220R, G54E and G54W mutations) and we successfully identified in this study two new mutations (N248K/V436A, Y433N substitution) conferrin ...[more]