Dataset Information

Prospective evaluation of glutamine and phospholipids levels in first degree relatives of patients with Type 1 Diabetes from a multiethnic population.

ABSTRACT:

Background

A dysregulation in the metabolism of lipids may be an early marker of autoimmunity in Type 1 Diabetes (T1D). It would be of general importance to identify metabolic patterns that would predict the risk for T1D later in life. The aim of this study was to perform a prospective evaluation of glutamine and phospholipids levels in Brazilian first degree relatives (FDR) of patients with T1D in a mean interval of 5 years.

Findings

Brazilian FDR (n?=?30) of patients with T1D were evaluated and blood was sampled to measure the levels of glutamine and phospholipids in the fasting serum by quantitative colorimetric method. The tests were repeated after a mean interval of 5 years and compared to a control group (n?=?20). The FDR presented lower levels of phospholipids than controls (p?=?0.028), but not of glutamine (p?=?0.075). Phospholipids levels decreased over time (p?=?0.028) in FDR and were associated with Glutamic acid decarboxylase autoantibody (GADA) titers (p?=?0.045), autoantibody positivity (p?=?0.008) and PTPN22 polymorphisms (p?=?0.014).

Conclusions

In this Brazilian multiethnic population, there was a significant decrease in phospholipids levels in FDR in patients with T1D during a 5-year prospective follow-up, as well as a significant association between these metabolite, GADA and PTPN22 polymorphisms. For Glutamine no difference was found. These findings suggest that a dysregulation in the metabolism of lipids may precede the onset of the autoimmunity in T1D.

SUBMITTER: Araujo de Pina Cabral DB

PROVIDER: S-EPMC4469243 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Publications

Prospective evaluation of glutamine and phospholipids levels in first degree relatives of patients with Type 1 Diabetes from a multiethnic population.

Araujo de Pina Cabral D B DB Dantas J R JR Skärstrand H H Barone B B Carvalho F F Tortora R R Milech A A Vaziri-Sani F F Oliveira J E P JE Zajdenverg L L Rodacki M M

Diabetology & metabolic syndrome 20150610

<h4>Background</h4>A dysregulation in the metabolism of lipids may be an early marker of autoimmunity in Type 1 Diabetes (T1D). It would be of general importance to identify metabolic patterns that would predict the risk for T1D later in life. The aim of this study was to perform a prospective evaluation of glutamine and phospholipids levels in Brazilian first degree relatives (FDR) of patients with T1D in a mean interval of 5 years.<h4>Findings</h4>Brazilian FDR (n = 30) of patients with T1D we ...[more]

PMID: 26082806

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Dataset Information

Prospective evaluation of glutamine and phospholipids levels in first degree relatives of patients with Type 1 Diabetes from a multiethnic population.

Background

Findings

Conclusions

Publications

Prospective evaluation of glutamine and phospholipids levels in first degree relatives of patients with Type 1 Diabetes from a multiethnic population.

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