Ontology highlight
ABSTRACT:
SUBMITTER: Beristain-Covarrubias N
PROVIDER: S-EPMC4693717 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Beristain-Covarrubias Nonantzin N Canche-Pool Elsy E Gomez-Diaz Rita R Sanchez-Torres Luvia E LE Ortiz-Navarrete Vianney V
Immunity, inflammation and disease 20150818 4
Type 1 diabetes (T1D) is an autoimmune disease that is characterized by the specific destruction of insulin-producing pancreatic β cells. Invariant natural killer T (iNKT) cells have been associated with development of T1D. Class I MHC-restricted T cell-associated molecule (CRTAM) is expressed on activated iNKT, CD8(+), and CD4(+) T cells, and it is associated with the pro-inflammatory profiles of these cells. Crtam gene expression in CD3(+) lymphocytes from non-obese diabetic (NOD) mice is asso ...[more]