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Gammadelta (??) T lymphocytes do not impact the development of early atherosclerosis.

ABSTRACT: Gammadelta (??) T cells are a subset of pro-inflammatory innate-like T lymphocytes that serve as a bridge between innate and adaptive immunity. ?? T cells are highly enriched in cholesterol compared to ?? T cells. In this study, we aimed to identify the role of ?? T cells in atherosclerosis, a cholesterol and inflammation-driven disease.We found that the percentages of ?? T cells are increased in ApoE(-/-) mice fed a Western diet. We generated TCR?(-/-)ApoE(-/-) mice and fed them either rodent chow or a Western diet for ten weeks for the assessment of atherosclerosis.The atherosclerotic lesion size in diet-fed TCR?(-/-)ApoE(-/-) mice was similar to that of diet-fed ApoE(-/-) mice. There were no differences in cytokine production or numbers of ?? T cells in aorta of TCR?(-/-)ApoE(-/-) mice. Plasma lipoprotein profiles were unchanged by the absence of ?? T cells.Our data suggest that ?? T cells do not contribute to early atherosclerotic plaque development.

SUBMITTER: Cheng HY

PROVIDER: S-EPMC4469487 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Gammadelta (γδ) T lymphocytes do not impact the development of early atherosclerosis.

Cheng Hsin-Yuan HY Wu Runpei R Hedrick Catherine C CC

Atherosclerosis 20140320 2

<h4>Objective</h4>Gammadelta (γδ) T cells are a subset of pro-inflammatory innate-like T lymphocytes that serve as a bridge between innate and adaptive immunity. γδ T cells are highly enriched in cholesterol compared to αβ T cells. In this study, we aimed to identify the role of γδ T cells in atherosclerosis, a cholesterol and inflammation-driven disease.<h4>Methods</h4>We found that the percentages of γδ T cells are increased in ApoE(-/-) mice fed a Western diet. We generated TCRδ(-/-)ApoE(-/-) ...[more]

PMID: 24704628

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