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Small-molecule-mediated axonal branching in Caenorhabditis elegans.

ABSTRACT: An in vivo system for monitoring small-molecule-mediated neuronal branching has been developed by using C. elegans. Growth-promoting compounds can be detected by visual inspection of GFPlabeled cholinergic neurons, as axonal branching occurs following treatment with neurotrophic agents. Investigation of the structure-activity relationship of the neurotrophic natural product clovanemagnolol (1) led us to a comparable chemically edited derivative.

SUBMITTER: Zlotkowski K 

PROVIDER: S-EPMC4470382 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Small-molecule-mediated axonal branching in Caenorhabditis elegans.

Zlotkowski Katherine K   Pierce-Shimomura Jon J   Siegel Dionicio D  

Chembiochem : a European journal of chemical biology 20130129 3

An in vivo system for monitoring small-molecule-mediated neuronal branching has been developed by using C. elegans. Growth-promoting compounds can be detected by visual inspection of GFPlabeled cholinergic neurons, as axonal branching occurs following treatment with neurotrophic agents. Investigation of the structure-activity relationship of the neurotrophic natural product clovanemagnolol (1) led us to a comparable chemically edited derivative. ...[more]

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