Small-molecule-mediated axonal branching in Caenorhabditis elegans.
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ABSTRACT:
SUBMITTER: Zlotkowski K
PROVIDER: S-EPMC4470382 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Publications
Small-molecule-mediated axonal branching in Caenorhabditis elegans.
Zlotkowski Katherine K Pierce-Shimomura Jon J Siegel Dionicio D
Chembiochem : a European journal of chemical biology 20130129 3
An in vivo system for monitoring small-molecule-mediated neuronal branching has been developed by using C. elegans. Growth-promoting compounds can be detected by visual inspection of GFPlabeled cholinergic neurons, as axonal branching occurs following treatment with neurotrophic agents. Investigation of the structure-activity relationship of the neurotrophic natural product clovanemagnolol (1) led us to a comparable chemically edited derivative. ...[more]
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