Ontology highlight
ABSTRACT:
SUBMITTER: Khalifa MM
PROVIDER: S-EPMC4470429 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Tetrahedron letters 20150701 27
We describe an efficient method for the direct preparation of <i>N</i>-substituted aryl amidines from nitriles and primary amines. The protocol employs activation of amines by a strong base and provides greater access to a pharmaceutically relevant functional group. This synthetic approach tolerates deactivated nitriles, nitriles with competing substitution sites, and aryl amines. ...[more]