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Synthesis and Single Crystal Structures of Substituted-1,3-Selenazol-2-amines.

ABSTRACT: The synthesis and X-ray single crystal structures of a series of new 4-substituted-1,3-selenazol-2-amines is reported. The efficient preparation of these compounds was carried out by two-component cyclization of the selenoureas with equimolar amounts of ?-haloketones. The selenoureas were obtained from the reaction of Woollins' reagent with cyanamides, followed by hydrolysis with water. All new compounds have been characterized by IR spectroscopy, multi-NMR (¹H, ¹³C, ⁷⁷Se) spectroscopy, accurate mass measurement and single crystal X-ray structure analysis.

SUBMITTER: Hua G

PROVIDER: S-EPMC6155636 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature

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Synthesis and Single Crystal Structures of Substituted-1,3-Selenazol-2-amines.

Hua Guoxiong G Du Junyi J Slawin Alexandra M Z AM Woollins J Derek JD

Molecules (Basel, Switzerland) 20161229 1

The synthesis and X-ray single crystal structures of a series of new 4-substituted-1,3-selenazol-2-amines is reported. The efficient preparation of these compounds was carried out by two-component cyclization of the selenoureas with equimolar amounts of α-haloketones. The selenoureas were obtained from the reaction of Woollins' reagent with cyanamides, followed by hydrolysis with water. All new compounds have been characterized by IR spectroscopy, multi-NMR (¹H, <sup>13</sup>C, <sup>77</sup>Se) ...[more]

PMID: 28036080

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