Ontology highlight
ABSTRACT:
SUBMITTER: Sahoo D
PROVIDER: S-EPMC4470476 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Sahoo Dipankar D Quesne Matthew G MG de Visser Sam P SP Rath Sankar Prasad SP
Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 20150130 16
A key step in cytochrome P450 catalysis includes the spin-state crossing from low spin to high spin upon substrate binding and subsequent reduction of the heme. Clearly, a weak perturbation in P450 enzymes triggers a spin-state crossing. However, the origin of the process whereby enzymes reorganize their active site through external perturbations, such as hydrogen bonding, is still poorly understood. We have thus studied the impact of hydrogen-bonding interactions on the electronic structure of ...[more]