Ontology highlight
ABSTRACT:
SUBMITTER: Hsiao JY
PROVIDER: S-EPMC4470865 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Hsiao Jennifer Y JY Goins Lauren M LM Petek Natalie A NA Mullins R Dyche RD
Current biology : CB 20150528 12
Tropomyosins are coiled-coil proteins that bind actin filaments and regulate multiple cytoskeletal functions, including actin network dynamics near the leading edge of motile cells. Previous work demonstrated that tropomyosins inhibit actin nucleation by the Arp2/3 complex and prevent filament disassembly by cofilin. We find that the Arp2/3 complex and cofilin, in turn, regulate the binding of tropomyosin to actin filaments. Using fluorescence microscopy, we show that tropomyosin (non-muscle Dro ...[more]