Binding of S100A6 to actin and the actin-tropomyosin complex.
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ABSTRACT:
SUBMITTER: Jurewicz E
PROVIDER: S-EPMC7393103 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Binding of S100A6 to actin and the actin-tropomyosin complex.
Jurewicz Ewelina E Robaszkiewicz Katarzyna K Moraczewska Joanna J Filipek Anna A
Scientific reports 20200730 1
S100A6 is a low molecular weight Ca<sup>2+</sup>-binding protein belonging to the S100 family. Many reports indicate that in the cell S100A6 has an influence on the organization of actin filaments, but so far no direct interaction between S100A6 and actin has been shown. In the present study we investigated binding of S100A6 to actin and the actin-tropomyosin complex. The analyses were performed on G- and F-actin and two tropomyosin isoforms-Tpm1.6 and Tpm1.8. Using purified proteins and a varie ...[more]
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