Ontology highlight
ABSTRACT:
SUBMITTER: Paul M
PROVIDER: S-EPMC4471342 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Paul Manoj M Hemshekhar Mahadevappa M Thushara Ram M RM Sundaram Mahalingam S MS NaveenKumar Somanathapura K SK Naveen Shivanna S Devaraja Sannaningaiah S Somyajit Kumar K West Robert R Basappa Nayaka Siddaiah C SC Zakai Uzma I UI Nagaraju Ganesh G Rangappa Kanchugarakoppal S KS Kemparaju Kempaiah K Girish Kesturu S KS
PloS one 20150617 6
Thrombocytopenia in methotrexate (MTX)-treated cancer and rheumatoid arthritis (RA) patients connotes the interference of MTX with platelets. Hence, it seemed appealing to appraise the effect of MTX on platelets. Thereby, the mechanism of action of MTX on platelets was dissected. MTX (10 μM) induced activation of pro-apoptotic proteins Bid, Bax and Bad through JNK phosphorylation leading to ΔΨm dissipation, cytochrome c release and caspase activation, culminating in apoptosis. The use of specifi ...[more]