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Targeting the canonical Wnt/?-catenin pathway in hematological malignancies.

ABSTRACT: The canonical Wnt/?-catenin pathway plays an important role in different developmental processes through the regulation of stem cell functions. In the activation of the canonical Wnt/?-catenin pathway, ?-catenin protein is imported into the nucleus and activates transcription of target genes including cyclin D1 and c-myc. Aberrant activation of the Wnt/?-catenin pathway contributes to carcinogenesis and malignant behaviors, and Wnt signaling is essential for the maintenance of cancer stem cells. The canonical Wnt/?-catenin pathway has been investigated extensively as a target in cancer treatment and several specific inhibitors of this signaling pathway have been identified through high-throughput screening. In this review, the significance of the canonical Wnt/?-catenin pathway in hematological carcinogenesis and screening methods for specific inhibitors are discussed.

SUBMITTER: Ashihara E

PROVIDER: S-EPMC4471797 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Targeting the canonical Wnt/β-catenin pathway in hematological malignancies.

Ashihara Eishi E Takada Tetsuya T Maekawa Taira T

Cancer science 20150401 6

The canonical Wnt/β-catenin pathway plays an important role in different developmental processes through the regulation of stem cell functions. In the activation of the canonical Wnt/β-catenin pathway, β-catenin protein is imported into the nucleus and activates transcription of target genes including cyclin D1 and c-myc. Aberrant activation of the Wnt/β-catenin pathway contributes to carcinogenesis and malignant behaviors, and Wnt signaling is essential for the maintenance of cancer stem cells. ...[more]

PMID: 25788321

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