Ontology highlight
ABSTRACT:
SUBMITTER: Fang F
PROVIDER: S-EPMC6298399 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Fang Fang F VanCleave Ashley A Helmuth Ralph R Torres Haydee H Rickel Kirby K Wollenzien Hannah H Sun Hongli H Zeng Erliang E Zhao Jing J Tao Jianning J
Oncotarget 20181204 95
Aberrant activation of Wnt signaling has been implicated in human osteosarcoma, which may provide a genetic vulnerability that can be targeted in osteosarcoma treatment. To test whether Wnt activation is necessary for osteosarcoma growth, colony formation, invasion, and metastasis, we treated human osteosarcoma cells with a small molecule inhibitor of Wnt/β-catenin, PRI-724, which suppresses Wnt/β-catenin-mediated transcription. We found increased protein levels of endogenous active-β-catenin in ...[more]