Ontology highlight
ABSTRACT:
SUBMITTER: Rogala KB
PROVIDER: S-EPMC4471805 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Rogala Kacper B KB Dynes Nicola J NJ Hatzopoulos Georgios N GN Yan Jun J Pong Sheng Kai SK Robinson Carol V CV Deane Charlotte M CM Gönczy Pierre P Vakonakis Ioannis I
eLife 20150529
Centrioles are microtubule-based organelles crucial for cell division, sensing and motility. In Caenorhabditis elegans, the onset of centriole formation requires notably the proteins SAS-5 and SAS-6, which have functional equivalents across eukaryotic evolution. Whereas the molecular architecture of SAS-6 and its role in initiating centriole formation are well understood, the mechanisms by which SAS-5 and its relatives function is unclear. Here, we combine biophysical and structural analysis to ...[more]