Unknown

Dataset Information

0

Longitudinal effects of intravenous immunoglobulin on Alzheimer's cerebrospinal fluid proteome.


ABSTRACT: Intravenous immunoglobulin (IVIg) therapy has shown promise in the treatment of Alzheimer's disease (AD). In this study, serial cerebrospinal fluid (CSF) samples from a group of subjects with AD undergoing IVIg immunotherapy are analyzed to identify IVIg-related changes. CSF samples from eight subjects were collected before therapy, after 6 months of therapy, and after a 3-month drug washout period. Samples were analyzed using a gel-based proteomics strategy and IVIg-related changes were determined by gel spot percent volumes. An initial assessment of the data revealed consistent and considerable change in 69 spots. A statistical analysis revealed 79 protein spots with a significant change after 6 months; furthermore, in a subset of these (25), the percent volume change was either maintained or reversed in the washout samples. The proteins that showed a significant change during IVIg therapy, including Ig molecules, gelsolin, transferrin, and transthyretin, have been previously implicated in AD. This study provides preliminary findings regarding a group of CSF proteins that may be associated with the treatment of AD, as well as the potential use of IVIg as an AD immunotherapy.

SUBMITTER: Shayan G 

PROVIDER: S-EPMC4471863 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Longitudinal effects of intravenous immunoglobulin on Alzheimer's cerebrospinal fluid proteome.

Shayan Gilda G   Adamiak Basia B   Choe Leila H LH   Relkin Norman N   Lee Kelvin H KH  

Electrophoresis 20140701 12-13


Intravenous immunoglobulin (IVIg) therapy has shown promise in the treatment of Alzheimer's disease (AD). In this study, serial cerebrospinal fluid (CSF) samples from a group of subjects with AD undergoing IVIg immunotherapy are analyzed to identify IVIg-related changes. CSF samples from eight subjects were collected before therapy, after 6 months of therapy, and after a 3-month drug washout period. Samples were analyzed using a gel-based proteomics strategy and IVIg-related changes were determi  ...[more]

Similar Datasets

| S-EPMC5827947 | biostudies-literature
| S-EPMC4780771 | biostudies-literature
| S-EPMC3594777 | biostudies-literature
| S-EPMC7266499 | biostudies-literature
| S-EPMC8947516 | biostudies-literature
| S-EPMC5562658 | biostudies-other
2019-11-04 | GSE134578 | GEO
| S-EPMC6052524 | biostudies-literature
| S-EPMC2881861 | biostudies-literature
| S-EPMC4879483 | biostudies-literature