ASXL2 Regulates Glucose, Lipid, and Skeletal Homeostasis.
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ABSTRACT:
SUBMITTER: Izawa T
PROVIDER: S-EPMC4472564 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
ASXL2 Regulates Glucose, Lipid, and Skeletal Homeostasis.
Izawa Takashi T Rohatgi Nidhi N Fukunaga Tomohiro T Wang Qun-Tian QT Silva Matthew J MJ Gardner Michael J MJ McDaniel Michael L ML Abumrad Nada A NA Semenkovich Clay F CF Teitelbaum Steven L SL Zou Wei W
Cell reports 20150604 10
ASXL2 is an ETP family protein that interacts with PPARγ. We find that ASXL2-/- mice are insulin resistant, lipodystrophic, and fail to respond to a high-fat diet. Consistent with genetic variation at the ASXL2 locus and human bone mineral density, ASXL2-/- mice are also severely osteopetrotic because of failed osteoclast differentiation attended by normal bone formation. ASXL2 regulates the osteoclast via two distinct signaling pathways. It induces osteoclast formation in a PPARγ/c-Fos-dependen ...[more]
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