Ontology highlight
ABSTRACT:
SUBMITTER: Ahn B
PROVIDER: S-EPMC5004938 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Ahn Byungyong B Soundarapandian Mangala M MM Sessions Hampton H Peddibhotla Satyamaheshwar S Roth Gregory P GP Li Jian-Liang JL Sugarman Eliot E Koo Ada A Malany Siobhan S Wang Miao M Yea Kyungmoo K Brooks Jeanne J Leone Teresa C TC Han Xianlin X Vega Rick B RB Kelly Daniel P DP
The Journal of clinical investigation 20160808 9
Intramuscular lipid accumulation is a common manifestation of chronic caloric excess and obesity that is strongly associated with insulin resistance. The mechanistic links between lipid accumulation in myocytes and insulin resistance are not completely understood. In this work, we used a high-throughput chemical biology screen to identify a small-molecule probe, SBI-477, that coordinately inhibited triacylglyceride (TAG) synthesis and enhanced basal glucose uptake in human skeletal myocytes. We ...[more]