Ontology highlight
ABSTRACT:
SUBMITTER: Kile AC
PROVIDER: S-EPMC4475461 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Kile Andrew C AC Chavez Diana A DA Bacal Julien J Eldirany Sherif S Korzhnev Dmitry M DM Bezsonova Irina I Eichman Brandt F BF Cimprich Karlene A KA
Molecular cell 20150604 6
Stalled replication forks are a critical problem for the cell because they can lead to complex genome rearrangements that underlie cell death and disease. Processes such as DNA damage tolerance and replication fork reversal protect stalled forks from these events. A central mediator of these DNA damage responses in humans is the Rad5-related DNA translocase, HLTF. Here, we present biochemical and structural evidence that the HIRAN domain, an ancient and conserved domain found in HLTF and other D ...[more]