Ontology highlight
ABSTRACT:
SUBMITTER: Gergely S
PROVIDER: S-EPMC4475553 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Gergely Szabolcs S Hegedűs Csaba C Lakatos Petra P Kovács Katalin K Gáspár Renáta R Csont Tamás T Virág László L
Oxidative medicine and cellular longevity 20150607
Antracyclines are effective antitumor agents. One of the most commonly used antracyclines is doxorubicin, which can be successfully used to treat a diverse spectrum of tumors. Application of these drugs is limited by their cardiotoxic effect, which is determined by a lifetime cumulative dose. We set out to identify by high throughput screening cardioprotective compounds protecting cardiomyocytes from doxorubicin-induced injury. Ten thousand compounds of ChemBridge's DIVERSet compound library wer ...[more]